The effect of background selection against deleterious mutations on weakly selected, linked variants
نویسندگان
چکیده
منابع مشابه
Deleterious background selection with recombination.
An analytic expression for the expected nucleotide diversity is obtained for a neutral locus in a region with deleterious mutation and recombination. Our analytic results are used to predict levels of variation for the entire third chromosome of Drosophila melanogaster. The predictions are consistent with the low levels of variation that have been observed at loci near the centromeres of the th...
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The effects of deleterious mutations on evolution at linked sites.
The process of evolution at a given site in the genome can be influenced by the action of selection at other sites, especially when these are closely linked to it. Such selection reduces the effective population size experienced by the site in question (the Hill-Robertson effect), reducing the level of variability and the efficacy of selection. In particular, deleterious variants are continuall...
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ژورنال
عنوان ژورنال: Genetical Research
سال: 1994
ISSN: 0016-6723,1469-5073
DOI: 10.1017/s0016672300032365